Flowering occurs throughout much of the year, depending on environmental conditions. Syconia are generally produced continuously, and trees within the same population often flower at different times.
Specialized fig wasps in the family Agaonidae pollinate the flowers by entering the syconium through the ostiole.
Birds and mammals help disperse the seeds by eating the fruit.
Several species are related to Ficus maxima, including the Panama rubber tree (Castilla elastica). This tropical tree can grow 20 to 40 metres tall and shares many physical characteristics with Ficus maxima. It is native to Mexico, Central America, and northern South America. Its latex, like that of several other tropical trees in the mulberry family (Moraceae), was once used to make rubber.