In August 2008, Charles-Mathieu Brunelle became director of Space for Life, the largest natural-sciences museum complex in Canada, consisting of the Biodôme, the Insectarium, the Jardin botanique and the Planétarium Rio Tinto Alcan.
Previously he was a founding member and first executive director of TOHU. He has also been associated with a number of achievements that have left their mark on the cultural life of Montréal, including with Compagnie Marie Chouinard and the Cinémathèque québécoise.
Charles-Mathieu Brunelle has sat on several boards of directors, among them those of the Conseil des arts et des lettres du Québec and the tourist industry advisory committee.
A sought-after lecturer, he has contributed to such events as the World Conference on the Development of Cities in Porto Alegre, Brazil, in 2008, and the 11th United Nations Conference of the Parties in Hyderabad, India, in 2012.